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‘A most confounding affliction’: A look at headaches

Adult man Depression concept.
Tatiana Maksimova
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Moment RF / Getty Images

Headache symptoms can strike sufferers without warning, disabling them for even days at a time.

There have been nearly 4,000 years of documented headache disorders — and virtually everyone has had headaches — yet their underlying neurological cause is still unknown.

This hour, a look at the long history of headaches and the current science around and treatments for headaches. Plus: headaches in our literature and popular culture.

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Colin McEnroe and Dylan Reyes contributed to this show.

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Jonathan is a producer for ‘The Colin McEnroe Show.’ His work has been heard nationally on NPR and locally on Connecticut Public’s talk shows and news magazines. He’s as likely to host a podcast on minor league baseball as he is to cover a presidential debate almost by accident. Jonathan can be reached at jmcnicol@ctpublic.org.
Isaac Moss is a Talk Show Production Intern for summer 2025. In her free time, she can be found gardening, cooking, and embarking on epic quests.